JAG1 anticorps (C-Term)

N° du produit ABIN6992092

Cet anticorps Lapin Polyclonal détecte spécifiquement JAG1 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour JAG1 anticorps (C-Term) (ABIN6992092)

Antigène: JAG1 (Jagged 1 (JAG1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JAG1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-JAG1 anticorps

Épitope: C-Term

Specificité: JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist, this antibody will detect both isoforms.

Purification: JAG1 antibody is affinity chromatography purified via peptide column.

Immunogène: JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is located within the last 50 amino acids of JAG1.

Isotype: IgG

Information d'application

Indications d'application: JAG1 antibody can be used for detection of JAG1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: JAG1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: JAG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur JAG1

Antigène: JAG1 (Jagged 1 (JAG1))

Autre désignation: JAG1

Sujet: The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1). Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2). JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3). JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5).

Poids moléculaire: Predicted: 134 kDa

Observed: 130 kDa

ID gène: 182

NCBI Accession: NP_000205

UniProt: P78504

Pathways: Signalisation Notch, Stem Cell Maintenance